Deciduous Therapeutics aims to positively impact human health span through the development of novel medicines that activate the endogenous immune mechanism responsible for the elimination of senescent cells.

Our Science

Senescent cells, which are characterized by irreversible damage and an inflammatory secretome, are considered a key driving force behind many age-related diseases. Due to a failure in immune surveillance, senescent cells accumulate and impact their local environment by inducing inflammation and promoting extracellular matrix remodeling, thus resulting in a myriad of metabolic and fibrotic consequences. Therefore, enabling the removal of senescent cells dramatically ameliorates disease pathologies in many age-related diseases, leading to overall improvements in health-span.

At Deciduous Therapeutics, we have discovered novel molecules that can activate a critical endogenous immune surveillance mechanism to selectively remove senescent cells and thereby treat several classes of age-related diseases

Our Team

Our team is composed of scientists, entrepreneurs, and drug hunters who share a collective vision and passion for profoundly impacting how we age.

Research Associate II

Jasmine Denny

Jasmine joined Deciduous from the University of California Santa Barbara where she studied Pharmacology. She works with the research team to support a variety of in vivo studies. She is also engaged with the Fallen Waterman's foundation to fundraise for higher education.
VP of Research

Scott Armstrong

Scott Armstrong is an experienced in vivo pharmacologist with a passion for drug discovery and development. He brings over 25 years of research experience across a broad range of therapeutic areas. Most recently, he was the Head of In Vivo Pharmacology at Unity Biotechnology. There, he led the respiratory disease project team while managing a function that was focused on musculoskeletal, ocular and hepatic drug discovery. Prior to Unity, Scott was the founding lab biologist at Theravance Biopharma and spent 19 years in roles of increasing leadership contributing to 10 IND filings and 2 approved drugs (Vibativ®, Yupelri®). In his free time, he enjoys travel, soccer, and Sunday mornings reading the New York Times.
Scientific Founder

Anil Bhushan

Dr. Anil Bhushan is the scientific founder of Deciduous where his lab was one of the first to show the role of clearing senescent cells in models of Type 1 diabetes. The long-term goal of his research is to understand the role of tissue secretory senescent cells in aging, autoimmunity and metabolic diseases. Recently they showed that pancreatic beta cells acquire a secretome in T1D in both mice and humans and exhibit many non-cell autonomous properties. Subsequently they have identified key immune cells that can selectively eliminate senescent beta cells to halt progression of beta cell destruction to prevent T1D in mouse models. They now utilize immune modulatory targets to identify new drugs that specifically eliminate secretory senescent cells in humans.
Research Associate

Philippine Alba

As a research associate, Philippine supports the in vivo team in therapeutic efficacy studies. Her passion for science began when she served as a biology tutor and undergraduate researcher at Bard College in New York, where she earned a B.A. in Biology. She brings to Deciduous animal handling and sample prep experience gained as a veterinary assistant or technician at the VCA San Francisco Veterinary Specialists or Explora BioLabs respectively. Philippine was born in France and grew up in California. She has two cats named Hazel and Bagheera.
Scientist

Connor Wander

Connor Wander, PhD, is a Research Scientist at Deciduous Therapeutics, Inc and a recent graduate from the Pharmacology Department at UNC Chapel Hill. As a co-mentored student between the Cohen and Song Labs at UNC, Connor studied glial biology, adult neurogenesis, and inhibitory neural networks in Alzheimer's Disease. His other scientific interests include the interactions between the environment, genetics, and nutrition in neurodegenerative diseases. Connor also founded Straight from a Scientist, a science education website with podcast episodes and web games on neuroscience, astrophysics, virology, and more. Outside of the sciences, Connor enjoys hobbies such as graphic design, balcony gardening, gaming, Brazilian Jiu Jitsu, paintball and caring for his bearded dragons.
Chief Operating Officer

Leah Makley

Dr. Leah Makley is COO of Deciduous Therapeutics. Previously, she co-founded and served as CSO then CEO of ViewPoint Therapeutics, a venture-backed biotechnology startup developing medical treatments for aging-related protein misfolding diseases of the eye, including cataracts and presbyopia. Leah earned her PhD in Medicinal Chemistry from the University of Michigan, where she used biophysical assays to identify, optimize, and characterize small molecule modulators of small heat shock structure and function. In her free time, Leah enjoys baking, painting, and dancing, and prefers to spend as much time outdoors as possible.
Toxicology Lead

Janice Lansita

Dr. Janice Lansita is a board-certified toxicologist with over 16 years of experience, both in the biopharmaceutical industry and with the Food and Drug Administration (FDA). As a regulatory toxicologist, she has developed small molecule as well as biologic therapies, including monoclonal antibodies, bispecifics, fusion proteins, cytokines, cell and gene therapies, peptides, enzyme replacement therapies, and DNA/RNA based therapies for a broad range of indications (e.g., rare disease, oncology, neurology, pain, ophthalmology, and immunology). Dr. Lansita has extensive experience in the design, monitoring, and interpretation of nonclinical toxicology studies (GLP and non-GLP) and has authored the nonclinical sections of various regulatory documents, including pre-INDs, INDs/CTAs (>30), Investigator Brochures, annual reports, BLAs/NDAs, and package inserts/product labels for biopharmaceuticals. She has specialized expertise in the nonclinical development of biologic therapeutics, including pharmacologically relevant species selection, immunogenicity, immune-mediated toxicity (e.g., complement activation, anti-drug antibodies, autoimmunity, cytokine-release), surrogate animal models, immunotoxicology endpoints, study design and setting the FIH starting dose (MABEL, HNSTD, NOAEL).
Chief of Staff

Rachel Hatano

Dr. Rachel Hatano was one of the first scientists at Deciduous Therapeutics, and established a range of target validation, in vitro screening, and functional characterization bioassay experiments critical to vetting novel immunotherapies. Her current role focuses on enabling the company's operations initiatives. Rachel received her PhD in Bioengineering at University of California, Merced, where she focused on cardiovascular tissue engineering & integrated cellular systems. In addition, Rachel is an advocate/active mentor for minorities in STEM programs in the Bay Area and California central valley.
CEO and Co-Founder

Robin Manusukhani

Robin Mansukhani is CEO and Co-Founder of Deciduous Therapeutics. Previously, he co-founded and served as President & CEO of Alzeca Biosciences, an Alzheimer’s/CNS diagnostic imaging company which was supported by venture investors and the NIH. He has been an invited speaker both domestically and abroad, including TEDx. Previously Robin has worked in early stage venture capital at The Maple Fund and investment banking at Axiom Capital. In the community, he co-founded BlueStamp Engineering, an intensive, project based engineering program for high school students in NYC, San Francisco, and Palo Alto. He has also served a term in AmeriCorps. Mr. Mansukhani holds a B.S. in Biochemistry from Case Western Reserve University. He lives in San Francisco with his wife, three daughters, and indefatigable dog. He enjoys cooking and exercise, sometimes in that order.
Senior Research Associate

Jack Galloway

Jack Galloway supports all of Deciduous’ in vivo experiments with his broad range of murine model expertise. As a former research associate at Unity Biotechnology, Jack brings experience in a variety of surgery, tissue collection, and down-stream processing techniques. Prior to his work as a researcher, Jack received a Bachelor of Science in pharmacology from the University of California, Santa Barbara, where he competed on the varsity track and field team.
Scientist

Aritra Bhattacharyya

Aritra Bhattacharyya is an immunologist at Deciduous Therapeutics where his team is focused on activating the immune system for clearance of senescent cells in vivo. He has finished his postdoctoral training at the University of California, San Francisco SABRE center before completing his PhD from Humboldt Universität zu Berlin, Germany, funded by Jurgen Manchot Stiftung. Both during his PhD and Postdoctoral training, he studied the roles of the myeloid and mesenchymal compartment during various lung diseases such as bacterial pneumonia, idiopathic pulmonary fibrosis, asthma, and influenza infection.
Research Associate

Kelly Kusche

Kelly Kusche graduated from the University of California, Irvine with a Bachelor of Science degree in Pharmaceutical Sciences. After graduating, Kelly worked as a research associate at Gladstone Institutes, where she studied the use of optogenetics to extinguish OCD behaviors in mouse models. She is thrilled to be joining the in vivo research team at Deciduous to apply and expand her pharmaceutical knowledge and laboratory experience.
Medicinal Chemistry

Matt Duncton

Dr. Matt Duncton has over 20 years of experience in medicinal chemistry with a career working in oncology, immunology, anti-infectives and neuroscience therapeutic areas at companies such as Merck, Vernalis, OSI Pharmaceuticals, ImClone Systems, Renovis, and Rigel Pharmaceuticals. Since 2016, Matt has served as an independent consultant in medicinal chemistry working with small biopharmaceutical organizations, Venture Capital groups and academia. Matt is an author/inventor on more than 90 papers and patents and his work has led to projects advancing in to human clinical trials, such as ARX-1796 (recently licensed to Pfizer), NFX-179 (currently, Phase II), RN-5327 (TRPV1 antagonist; Phase I), and a host of other IND candidates.

Advisors

Investor & Advisor

Laura Deming

When she was 8, Laura Deming realized that we were all going to die of a disease called aging. Ever since, her driving passion has been to slow aging and eliminate age-related disease. She started working in a biogerontology lab when she was 12, and matriculated at MIT when she was 14. At 17, she was one of the youngest 20under20 fellows awarded $100,000 by Peter Thiel to pursue her venture full time. Laura is currently a full-time partner at The Longevity Fund, an early stage venture capital fund backing companies which target the aging process to treat disease, with investments in gene editing, small molecule therapeutics, and novel methods to treat disease.’
Board Member

Robert Forrester

Robert Forrester is the co-founder and CXO of EQRx. Robert has over 20 years of experience as the CEO, COO or CFO of both private and public life science companies with Verastem Oncology (NASDAQ: VSTM), Forma Therapeutics (NASDAQ: FMTX), CombinatoRx (NASDAQ: CRXX, now ZLCS) and Coley (NASDAQ: COLY, acquired by Pfizer). Robert was a managing director of the Proprietary Investment Group at MeesPierson, part of the Fortis Group, investing in life science companies. Prior to MeesPierson, Robert worked for the investment banks, Barclays Capital and UBS, in the corporate finance groups undertaking M&A, and public and private finance transactions. Robert started his career as lawyer with Clifford Chance in London and Singapore. Robert has completed approximately $20 billion of transactions and has been involved with five approved products. He holds a LL.B. from Bristol University.
Investor & Board Member

Dylan Morris

Dylan Morris is a former General Partner in CRV’s Bioengineering practice, and current Managing Partner at Insight Venture Partners. He has led investments in System1 Biosciences, Recursion Pharmaceuticals, 3T Biosciences, and Plexium. He previously invested at Innovation Endeavors, an early-stage venture firm backed by Eric Schmidt, of Google/Alphabet. At IE, Dylan drove investments in several companies operating at the intersection of computing and biology, including Freenome, a CRV portfolio company applying deep learning to liquid biopsy for early cancer detection. Previously, he cofounded Integrated Plasmonics, a venture-backed point-of-care diagnostics startup. Dylan conducted graduate research in Biophysics at Caltech and received an A.B. in Computer Science from Harvard.

Dylan is passionate about accelerating the future of biology. He is excited about opportunities that leverage data to make biological engineering more tractable. He cares deeply about human health and is eager to explore creative ways to stimulate research and hasten the pace of biomedical innovation.

Investor & Advisor

Karen Boezi

Karen Boezi is a member of Broadway Angels and the founding managing director of QB3's Executive Mentorship Program. She's also a co-founder of the new San Francisco Girls' School and Center of Excellence for Girls' STEM Education initiatives. Previously, Karen was the CEO of Redwood Bioscience which she joined as the first non-founder employee, leading the company through its successful acquisition by Catalent (CTLT). Redwood, now Catalent Biologics, continues to be a pioneer in developing therapeutic conjugate technology and antibody-drug conjugates for improving cancer treatment. Prior to joining Redwood, Karen was a co-founder and partner of Thomas, McNerney & Partners (TMP), a health care technology-focused venture firm with $600 million under management. TMP was recently recognized for managing one of the top three performing 2006 vintage venture funds globally. Previously, she was a General Partner of Coral Ventures and a member of Warburg Pincus LLC’s healthcare technology venture group. During her venture career, Karen was involved with 15 companies from initial investment that went public and/or were acquired; three of which she launched in collaboration with scientific founders. Karen began her career as a member of Alex. Brown & Sons’s health care and insurance corporate finance teams. She graduated Phi Beta Kappa and magna cum laude with a B.S. in Economics from the Wharton School at the University of Pennsylvania.
Advisor

Martin Babler

Mr. Babler previously served as Principia’s Chief Executive Officer starting in 2011, then as President and Chief Executive Officer between early 2019 and 2020. Principia, founded in 2008, built a portfolio of drugs to treat immune-mediated conditions including multiple sclerosis, pemphigus and immune thrombocytopenia purpura, all currently in Phase 3 trials. Martin Babler joined the company when it started operations in 2011 and led it through several rounds of financing, the IPO, and the acquisition by Sanofi for $3.7 billion.

From 2007 to 2011, Mr. Babler served as President and Chief Executive Officer of Talima Therapeutics. From 1998 to 2007, Mr. Babler held several positions at Genentech, most notably Vice President, Immunology Sales and Marketing. While at Genentech, he also helped build and led the Commercial Development organization and led the Cardiovascular Marketing organization. From 1991 to 1998, Mr. Babler was employed at Eli Lilly and Company in sales management, global marketing, and business development.

Advisor

Regis Kelly

Dr. Regis B. Kelly is the Director of one of four California Institutes for Science and Innovation, created by the California Legislature to strengthen the academic foundation of its technology-based industries. QB3 is the only one of the four devoted exclusively to biology and to the life science industries. It is an innovation center made up of over 200 quantitative biologists at three northern California campuses (UCB, UCSC & UCSF) working at the interface of the physical and biological sciences and a team of professionals converting its discoveries into practical benefits for society.

From 2000 to 2004, Dr. Kelly served as Executive Vice Chancellor at the University of California in San Francisco, where his major responsibility was the new Mission Bay campus.

SAB

Max Krummel

For the past 25 years, Max Krummel has used cutting-edge technologies to study the mechanisms that regulate the immune system, making discoveries that have led to numerous critical advances. For instance, while earning his doctorate at the University of California, Berkeley Max Krummel co-invented the first approved immunotherapy for cancer, which has now helped more than a hundred thousand people with cancer. As a graduate student in James Allison's lab, Krummel's work on key checkpoint inhibitors for cancer immunotherapy was instrumental in the 2018 Nobel prize awarded to Allison and Honjo. In 2015 Krummel founded Pionyr Immunotherapeutics, a now clinical-stage company with a diversified pipeline of myeloid targeting therapeutic antibodies. Through a 2020 alliance with Gilead, Pionyr is eligible to receive up to $1.74 billion through the purchase of exclusive options and future milestone payments.

Today, Krummel is an immunologist at the University of California, San Francisco, where he is laying the groundwork for the next generation of research as the co-founder of ImmunoX, an innovative research program that promotes collaboration, communication, and the sharing of data technology and findings across fields, disciplines, and geographies

SAB

Eric Verdin

Dr. Verdin is the president and chief executive officer of the Buck Institute for Research on Aging. A native of Belgium, Dr. Verdin received his Doctorate of Medicine (MD) from the University of Liege and completed additional clinical and research training at Harvard Medical School. He has held faculty positions at the University of Brussels, the National Institutes of Health (NIH), and the Picower Institute for Medical Research. Dr. Verdin is also a professor of medicine at University of California, San Francisco.

Dr. Verdin studies how metabolism, diet, and small molecules regulate the activity of HDACs and sirtuins, and thereby the aging process and its associated diseases, including Alzheimer’s. He has published more than 210 scientific papers and holds more than 15 patents. He is a highly cited scientist (top 1 percent) and has been recognized for his research with a Glenn Award for Research in Biological Mechanisms of Aging and a senior scholarship from the Ellison Medical Foundation. He is an elected member of several scientific organizations, including the American Association for the Advancement of Science, the American Society for Clinical Investigation, and the Association of American Physicians. He also serves on the advisory council of National Institute on Drug Abuse at the National Institutes of Health.

Dr. Verdin has extensive experience working with biotech companies. He is a founder of Acylin (purchased by Abbvie). He served on the scientific advisory boards of Elixir, Sirtris (purchased by GSK), Calico (Google), and Nokia, and he also served as advisor to Sofinnova Ventures. Dr. Verdin has also worked for several years as a consultant to Novartis, GSK, J&J, Altana, Roche, Pfizer, and other biotech companies.

SAB

Markus Grompe

Dr. Markus Grompe is a professor of Pediatrics and practicing physician at Oregon Health & Science University since 1991. Grompe is a specialist in hepatology and stem cell biology, and is known for the development of the "Fah mouse model", a transgenic mouse model of Type I tyrosinemia. The mice have been used to model diseases such as malaria and to optimize human gene therapy strategies.

In 2007 Grompe founded Yecuris Corporation, which distributes mice with "humanized" livers to pharmaceutical and biotech companies for pre-clinical research in infectious liver diseases, liver gene therapy, and drug metabolism.

In 2016, he cofounded Ambys Medicines where he currently serves as the CSO. Ambys develops treatments for advanced liver disease through enhancement or regeneration of hepatocyte activity.

News

Announcements

May 2021

Invariant natural killer T Cells coordinate removal of senescent cells

Failure of endogenous immune surveillance mechanisms to remove senescent cells drives the progression of diseases. The identity of the endogenous immune surveillance that mediated senescent cell clearance in vivo is not clear. This paper describes how lipid antigen presentation to activate iNKT cells can constitute an endogenous surveillance system that can be manipulated to clear senescent cells in disease models.

Read more
Oct 2022

The Deciduous Story

Deciduous will be presenting at The Rejuvenation Startup Summit in Berlin. If you are interested in learning more about our progress, we hope to see you there.

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June 2022

Harnessing Endogenous Immune Biology to Ablate Pathogenic Senescent Cells & Treat Disease

Deciduous CEO, Robin Mansukhani, is speaking at the 4th Annual Longevity Therapeutics Summit in San Francisco. Come say hello!

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April 2022

Harnessing endogenous immune biology to ablate pathogenic senescent cells and treat disease

Deciduous CEO, Robin Mansukhani, is speaking at the Longevity Leaders World Congress in London this April. Tune in to hear the story of how we’ve identified an endogenous immune mechanism for clearing senescent cells, therapeutically harnessed the immune system to remove senescent cells in a diseased state, and achieved therapeutically relevant endpoints and durable effects.

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November 2021

Eisai Innovation, Inc. and MBC BioLabs Announce Golden Ticket Winner

Eisai Innovation, Inc. and MBC BioLabs are happy to announce Deciduous Therapeutics as the winner of their 2021 Golden Ticket Competition. Eisai Innovation, Inc.’s inaugural competition provides the winning company’s entrepreneurial scientists and emerging biotechnology start-up with lab space in the MBC BioLabs facility to pursue drug discovery and innovation for the potential future benefit …

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Ocotber 2021

Deciduous Therapeutics Announces Appointments to the Board, SAB, and Advisor Roles

Deciduous Therapeutics, an early stage immune therapy start-up, announced today the appointment of an independent board member, additional Scientific Advisory Board members, and company advisors. Mr. Robert Forrester joins Deciduous as an Independent Board Member. He will be joining Robin Mansukhani, Deciduous’ Co-founder and CEO, Anil Bhushan, Scientific Founder of Deciduous, and Dylan Morris, Venture Partner at CRV. Mr. Forrester is …

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Ocotber 2021

Bakar Labs Awards Deciduous Therapeutics and Rubik Therapeutics 2021 Golden Tickets

Companies Can Access Free Lab Space and Facilities for a Year at UC Berkeley’s Flagship Bioscience Incubator BERKELEY, Calif., Oct. 21, 2021 /PRNewswire/ — Deciduous Therapeutics and Rubik Therapeutics have won 2021 Golden Tickets, granting the companies access to free lab space and facilities for a year, Bakar Labs announced today. The opportunity will give the …

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Press

Eliminating Senescent Cells by Activating the Immune System

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Reawakened immune cells show promise in mice against zombie cells tied to diseases of aging

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Can a rare immune cell offer the key to slowing down senescence? A Bay Area startup looks to find out

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Harnessing the immune system to target cellular senescence

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2021 in longevity – prolific terrific scientifics

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“Tuning the Immune Response” Featuring Dr. Anil Bhushan

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Investors

Careers

Enrich your Scientific Career

At Deciduous, we work as collaborative teams towards the discovery and advancement of novel therapies by utilizing each individual’s unique skills, insights, and creativity. View our current openings below.

Senior Scientist / Associate Director (Research)

San Francisco, CA
Full Time
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Research Scientist
(In Vivo)

San Francisco, CA
Full Time
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Research Associate
(In Vivo)

San Francisco, CA
Full Time
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Senior Research Associate / Associate Scientist

San Francisco, CA
Full Time
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Contact

For investor or press inquiries:

info@deciduoustx.com

Interested in joining us?

careers@deciduoustx.com

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San Francisco, CA 94107

info@deciduoustx.com
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